Sufficient evidence is now available to accept the concept that the brain recognizes cytokines as molecular signals of sickness. Clarifying the way the brain processes information generated by the innate immune system is accompanied by a progressive elucidation of the cellular and molecular components of the intricate system that mediates cytokine-induced sickness behavior. We are still far, however, from understanding the whole. Among the hundreds of genes that proinflammatory cytokines can induce in their cellular targets, only a handful has been examined functionally. In addition, a dynamic view of the cellular interactions that occur at the brain sites of cytokine production and action is missing, together with a clarification of the mechanisms that favor the transition toward pathology. Anyone who has experienced an episode of viral or bacterial infection knows well the subjective feelings of sickness, in the form of malaise, lassitude, fatigue, numbness, coldness, muscle and joint aches, and reduced appetite. Because they are common, these symptoms usually are ignored by physicians. They are considered uncomfortable, but banal, components of the pathogen-induced debilitation process that affects sick individuals. This simplistic view has turned out to be incorrect.
Education – Behaviours/Optredes (Gedrag)
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Can we ask you a few questions about EASY? More information. EASY can be searched via a general free-text search. It searches in the metadata of all published datasets, but it does not extend into the contents of the uploaded files in datasets. Please use English as well as Dutch words for optimal search results. A result list shows datasets that match the chosen criteria, mentioned in the ‘Criteria’ at the top of the list. Criteria may be removed individually using the ‘x’ mark beside them.
On most result lists, refine options are available at the right-hand side. Use those options to filter within the list e. For more about refining and the meaning of the values of the field ‘Access’, refer to the help on refine use the ‘? To get a list of all published datasets, start with the ‘Browse’ link. The objective of the study is to provide a better understanding of the possibilities for optimizing the central issue of VOG NP, including the assessment of the applicant and the work procedures.
EASY offers sustainable archiving of research data and access to thousands of datasets. Search scope EASY can be searched via a general free-text search.